This information is a bit technical when it comes to canabinoids and the skeletal system but I really wanted to find out if CBD may help with Osteoporosis. It takes a lot of time and one can get into a bit of a fix if you move too fast. This I’ve learned from the past, so I felt it best to rather give you more than less. This way you can choose how deep you want to go.
Endocannabinoids control basic biological processes including cell choice between survival and death and progenitor/stem cell proliferation and differentiation.
Basically a high percentage of canabinoid receptors are present in the skeletal sympathetic nerve terminals..
They are found to regulate and facilitate bone formation. It is discovered that a specific canabinoid CB2 is the main component associated with maintaining bone remodeling and keeping it at balance. Thus also protects the skeletal structure against age-related bone loss.
“Since the discovery of the endocannabinoid system, its presence and involvement have been reported in a handful of biological systems. Recently, the skeleton has been identified as a major endocannabinoid target through both the neuronal CB1 and predominantly peripheral CB2 cannabinoid receptors. CB1 is present in sympathetic nerve terminals in bone, whereas CB2 is expressed in osteoblasts and osteoclasts, the respective bone-forming and -resorbing cells.”
Furthermore, the skeleton appears as the main system physiologically regulated by CB2.
“CB2-deficient mice show a markedly accelerated age-related bone loss. The CB2 locus in women is associated with low bone density and osteoporotic fractures. Since activation of CB2 attenuates experimentally induced bone loss by inhibiting bone resorption and stimulating bone formation, and because synthetic cannabinoids are stable and orally available, a therapy based on synthetic CB2 agonists is a promising novel target for antiosteoporotic drug development.”
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